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Investigating the Metabolic Effects of the Cyclic Nucleotide Phosphodiesterase Inhibitors on Immature balb/c Mice

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Author(s): Seyyed Mohmmad Reza Parizadeh | Reza Shafiee-Nick | Maryam Sabery-Karimian | Majid Ghayour-Mobarhan | Gordon A.A. Ferns

Journal: Pakistan Journal of Nutrition
ISSN 1680-5194

Volume: 9;
Issue: 8;
Start page: 776;
Date: 2010;
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Keywords: Cyclic nucleotide phosphodiesterases | growth pattern | cAMP | cGMP

ABSTRACT
We have investigated the metabolic effects of IBMX (3-isobutyl-1-methyl xanthine, a non-selective PDE inhibitor), amrinone, MC7 (6-(4-(tetrahydro-2H-pyran-4-yl)-4-oxobutoxy)-4-methylquinolin-2(1H)-one) and MC9 (6-(4-(1-ethylpiperidin-4-yl)-4-oxobutoxy)-4-methylquinolin-2(1H)-one) (selective PDE3 inhibitors) on immature balb/c mice. Controls included groups of mice that received no intervention (control 1) and a group injected with 1mg/kg of drug carrier (control 2). The four experimental groups were weighed and injected separately with IBMX, amrinone, MC7 and MC9 (1mg/kg) daily for seven days after which they were killed and 59 blood and tissue samples were collected. The administration of drug carrier into the male mice, decreased the growth pattern during the second (P

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