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Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis

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Author(s): Haloom Rafehi | Katherine Ververis | Aneta Balcerczyk | Mark Ziemann | Jenny Ooi | Sean Hu | Faith A. A. Kwa | Shanon J. Loveridge | George T. Georgiadis | Assam El-Osta | Tom C. Karagiannis

Journal: Pathobiology of Aging & Age-related Diseases
ISSN 2001-0001

Volume: 2;
Start page: 1;
Date: 2012;
Original page

Keywords: cinnulin PF | diabetes | diabetic complications | diabetic ulcer | mRNA-Seq

ABSTRACT
The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF®, represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation. To access the supplementary material to this article: ‘Supplementary tables 1–3’ please see Supplementary files under Reading Tools online.
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