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Investigation of the Effects of Statin Therapy on Serum Vitamin E Status in Patients with Dyslipidemia

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Author(s): Majid Ghayour-Mobarhan | Amirhossein Sahebkar | B.J. Starkey | C. Livingstone | T. Wang | D.J. Lamb | G.A.A. Ferns

Journal: Pakistan Journal of Nutrition
ISSN 1680-5194

Volume: 7;
Issue: 4;
Start page: 561;
Date: 2008;
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Keywords: Atorvastatin | simvastatin | vitamin E | cholesterol | high sensitivity C-reactive protein (hs-CRP)

ABSTRACT
There are limited data on the effects of statins on serum vitamin E status in dyslipidaemic patients, and no comparisons between statins have been published previously. We have investigated the effect of Atorvastatin and Simvastatin on serum vitamin E status in dyslipidaemic patients. A total of 20 dyslipidaemic patients (14 males, 6 females, mean age 49.15±3.28 years), previously not treated with a lipid lowering agent, were recruited into the study. These patients were randomized to treatment group and received either: Simvastatin 10mg/day (n = 11) or Atorvastatin 10mg/day (n = 9) for 4 months. The control group comprised 14 patients from the same clinic, who were given lifestyle advice, but whose drug treatment remained unchanged for the duration of the study. Serum concentrations of vitamin E, high sensitivity C-reactive protein (hs-CRP) and fasted lipid profiles pre- and post-treatment were measured in all subjects. There were the expected significant reductions in serum lipids in the patients treated with either statin (P
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