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INVESTIGATION OF HEPATOPROTECTIVE ACTIVITY OF FICUS RETUSA (MORACEAE)

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Author(s): N. Jaya Raju | N. Sreekanth

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 1;
Start page: 166;
Date: 2011;
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Keywords: Hepatoprotective | Ficus retusa | Carbontetrachloride | Silymarin.

ABSTRACT
Ficus retusa (Moraceae) is distributed through out Western peninsula and also found in Chota Nagpur, Bihar, Central India, Andamans, Sundribuns, Malaya islands and Australia. In Sanskrit, it is known as ‘Kantalaka’, ‘Kshudra’ and in Telugu it is well known as ‘Yerrajuvvi’. Ficus leaves of ethyl acetate and methanolic extracts (100, 200 and 400 mg/kg) was prepared and tested for its hepatoprotective effect against carbon tetrachloride induced in rats. Alteration in the levels of biochemical markers of hepatic damage like SGPT, SGOT, ALP, bilirubin were tested in both treated and untreated groups. Carbon tetrachloride has enhanced the SGPT, SGOT, ALP and bilirubin levels. Treatment with ethyl acetate extract of Ficus retusa leaves has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner SGOT (213.1± 1.25, 198.2± 3.45, 180.6 ± 2.05), SGPT(195.1±2.22, 168.4±1.36, 112.6±3.24), ALKP(215.6±4.60, 202.3±2.45, 195.1±3.20) and T.B(1.24±0.01, 1.05±1.08, 0.96±0.13) levels respectively. Though both the extracts were recorded with significant hepatoprotective activity with same “p” value (p
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