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Investigation into iron chelating activity of Triticum aestivum (wheat grass) in iron-dextran induce iron overload model of thalassemia

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Author(s): P. R. Tirgar1*, T. R. Desai2

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3066;
Date: 2011;
Original page

Keywords: Triticum aestivum | iron overload | iron chelating property.

ABSTRACT
Triticum aestivum, wheatgrass is a cereal grass of Gramineae (Poaceae) family has been traditionally used, to treat various diseases like cancers, diabetes, gastritis,ulcers, pancreas and liver problems, anemia, skin problems etc. Wheat grass is a rich source of phenolic and flavanoid content, which known for antioxidants andalso possess chelating property. Iron overload is one of major causes of morbidity in all patients with severe forms of thalassemia and other iron overloadeddisorders. The present study was planned to evaluate beneficial effects and mechanism of action of T. aestivum on iron dextran induced iron overload animals.Water and methanol extracts of T. aestivum were found to be contains phenolic contents and also possess in-vitro iron chelating activity. We have made theunexpected observation that water and methanol extracts of T. aestivum strikingly reduce serum iron and ferritin levels compare to disease control group and whichis very near to desferoxamine group which is a standard iron chelator use in treatment of iron overload in thalassemia. Reduction in serum iron and ferritin leveris due to increase the excretion of iron in urine and faces, suggesting that Triticum aestivum have properties of an iron chelator. In conclusion, our data suggestTriticum aestivum possess beneficial effect in iron over load disorders due to its iron chelation property.
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