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Investigation of molecular biology of leukaemia inhibitory factor (LIF): A Bioinformatics approach.

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Author(s): Sanuwarul Kabir 1 , Abdullah-Al-Emran 2* , Zinnia Naoshin 3 , Farzana Ahmed 4

Journal: International Journal of Biosciences
ISSN 2220-6655

Volume: 1;
Issue: 3;
Start page: 20;
Date: 2011;
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Keywords: Leukemia inhibitory factor | bioinformatics | molecular properties | orthologs | paralogs.

ABSTRACT
Leukaemia inhibitory factor (LIF) is a glycoprotein with a variety of functions in different organ systems. It has great impact on embryogenic stem cell as it is required to maintain the differentiated state of a cell. In our study we tried to find out various molecular features of LIF in human such as conserved domains, important transcription factors, sequence motifs, protein motifs, conserved miRNA binding site and single nucleotide polymorphisms with the help of bioinformatics tools. We also tried to generate a generalized downstream signaling pathway for LIF. These findings could be used to control the expression of LIF for treatment and better drug designing.

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