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Investigation on the Antibacterial Activity and Mechanism of C12A7-O- Particles

Author(s): GONG Lu, SHEN Jing, LI Quan-Xin

Journal: Journal of Inorganic Materials
ISSN 1000-324X

Volume: 25;
Issue: 9;
Start page: 942;
Date: 2010;
Original page

Keywords: C12A7 | antibacterial activity | antibacterial mechanism

The [Ca24Al28O64]4+·4O-(C12A7-O-) particle was firstly investigated its antibacterial activity against bacteria E. Coli in aqueous solution and phosphate buffered saline (PBS). The C12A7-O- particles were synthesized by gas-solid reaction method with CaCO3 and γ-Al2O3 in a molar ratio of 12:7. The structure change of the C12A7-O- particles was measured by X-ray diffraction (XRD) and electron spin resonance (ESR) after antibacterial test. The results show that the structure of the C12A7-O- particles is completely changed into the structure of (CaO)3Al2O3·6H2O and Al(OH)3. In the C12A7-O- solution (1 mg/mL), the concentration of atomic oxygen anion (O-) in the solution is 4×1016 cm-3. In the antibacterial test with the particle concentration of 3 mg/mL in aqueous solution, the bacteria concentration in decreased by 99.98% in 1 h from the original concentration of 105 cfu/mL. When the particle concentration is 1 mg/mL in PBS, the pH is 7.4 and the pH effect of the solution could be neglected, but the bacteria concentration still deduces to 3.7×103 cfu/mL from the original concentration in 24 h. In briefly, O- is the main factor in the antibacterial test in the C12A7-O- PBS solution with the neutral pH environment.
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