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Involvement of stem cell in cancers

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Author(s): Arabinda Nayak

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3295;
Date: 2011;
Original page

Keywords: Stem cells | Cancer | Efficient Therapy

ABSTRACT
Stem cell biology has come of age. Cancer has been known to arise from long-lived cells in the body and to possess properties in common with undifferentiated,embryonic cells. Recent findings of a population of cells in solid tumors resembling stem cells supports a stem cell model of cancer. Unequivocal proof that stemcells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation oftheir properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful propertyof stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate fromthe transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include ‘cancerstem cells’ — rare cells with indefinite potential for self-renewal that drive tumorigenesis. This scheme helps explain the failure of many cancer therapies, pointsout deficiencies in certain research approaches, and focuses the problem on a subset of cells that can be explicitly targeted, leading to more efficient therapy.
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