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Iron as an agent of oxidative injury in experimental atherosclerosis

Author(s): Vučević Danijela | Radosavljević Tatjana | Mladenović D. | Čolić Jelena | Milovanović I. | Pešić B.Č. | Ješić-Vukićević Rada

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 61;
Issue: 5-6;
Start page: 631;
Date: 2011;
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Keywords: iron | experimental atherosclerosis | hypercholesterolemic diet | rabbits

Having in mind the importance of iron as a catalyst in some oxidative reactions, we examined the iron content in the serum and thoracic aorta tissue of rabbits with experimental atherosclerosis induced by hypercholesterolemic diet (4% solution of crystalline cholesterol in edible oil). For this study three groups of rabbits were used: C - control group fed a standard diet for this species (n=10), O - control group fed on an oil-containing diet (n=10) and Ch - experimental group fed on a hypercholesterolemic diet (n=10). Experimental atherosclerosis was pathohistologically confirmed. Iron content was quantified by atomic absorptive spectrophotometry. After two-months of treatment a highly significant increase of iron content was registred in the serum and thoracic aorta tissue in Group Ch (p
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