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Is High Dose Risperidone an Option for Treatment-Resistant Tourette Syndrome?

Author(s): Mazlum ÇÖPÜR | Baki ARPACI | Ş. Senem BAŞGÜL

Journal: Nöropsikiyatri Arşivi
ISSN 1300-0667

Volume: 46;
Issue: 4;
Start page: 206;
Date: 2009;
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Keywords: Tourette syndrome | risperidone | antipsychotics

Gilles de la Tourette syndrome (TS) is a chronic neuropsychiatric disorder that begins in childhood, in which multiple motor tics and one or more vocal tics are seen concomitantly. In this text, the treatment course of a severe TS case, with complete daily functioning loss, is described. Significant reductions in tics were observed with 8 mg/day risperidone treatment in this case who failed to respond to many neuroleptics. The Yale Global Tic Severity Scale (Y-GTSS) score, which was 85 before treatment, declined to 48. In our case, who used this dosing regimen for six months, the reduced tic status continued after the dose was switched to 6 mg/day, the reduction status was observed to go on after six months. No significant side effect was observed. This case was thought to be important in showing that high dose risperidone might be effective in treatment-resistant TS cases. (Archives of Neuropsychiatry 2009; 46: 206-8)

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