Academic Journals Database
Disseminating quality controlled scientific knowledge

The Ischemic Stroke Genetics Study (ISGS) Protocol

ADD TO MY LIST
 
Author(s): Meschia James | Brott Thomas | Brown Robert | Crook Richard | Frankel Michael | Hardy John | Merino José | Rich Stephen | Silliman Scott | Worrall Bradford Burke

Journal: BMC Neurology
ISSN 1471-2377

Volume: 3;
Issue: 1;
Start page: 4;
Date: 2003;
Original page

ABSTRACT
Abstract Background The molecular basis for the genetic risk of ischemic stroke is likely to be multigenic and influenced by environmental factors. Several small case-control studies have suggested associations between ischemic stroke and polymorphisms of genes that code for coagulation cascade proteins and platelet receptors. Our aim is to investigate potential associations between hemostatic gene polymorphisms and ischemic stroke, with particular emphasis on detailed characterization of the phenotype. Methods/Design The Ischemic Stroke Genetic Study is a prospective, multicenter genetic association study in adults with recent first-ever ischemic stroke confirmed with computed tomography or magnetic resonance imaging. Patients are evaluated at academic medical centers in the United States and compared with sex- and age-matched controls. Stroke subtypes are determined by central blinded adjudication using standardized, validated mechanistic and syndromic classification systems. The panel of genes to be tested for polymorphisms includes β-fibrinogen and platelet glycoprotein Ia, Iba, and IIb/IIIa. Immortalized cell lines are created to allow for time- and cost-efficient testing of additional candidate genes in the future. Discussion The study is designed to minimize survival bias and to allow for exploring associations between specific polymorphisms and individual subtypes of ischemic stroke. The data set will also permit the study of genetic determinants of stroke outcome. Having cell lines will permit testing of future candidate risk factor genes.
Affiliate Program     

Tango Rapperswil
Tango Rapperswil