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ISOLATION OF A NEW MODERATELY HALOPHILIC BROAD-SPECTRUM ANTIBIOTIC PRODUCING ACTINOBACTER

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Author(s): J Hamedi | F Mohammadipanah | MA Amoozegar | S Dehghan

Journal: Jundishapur Journal of Natural Pharmaceutical Products
ISSN 1735-7780

Volume: 2;
Issue: 2;
Start page: 94;
Date: 2007;
Original page

Keywords: Actinobacteria | Antibiotic | Halophile | MRSA | Nocardiopsis | Pseudomonas aeruginosa.

ABSTRACT
In a screening program for antibiotic producer rare-actinobacteria from soil of Iran, a novel moderately halophilic actinobacter (Q70) was isolated. The strain had the ability of antibiotic production against methicillin resistant Staphylococcus aureus. Maximum antibiotic production was obtained in the medium containing 10% (w/v) NaCl. The strain Q70 had also activity against Enterococcus faecalis, Bacillus subtilis and Pseudomonas aeruginosa. The antibiotic extracted from fermentation broth had low toxicity (681/3 μg/ml LC50) against Artemia salina in brine shrimp lethality test. The antibiotic produced by strain Q70 had polar structure. The strain Q70 is proposed as a new species with the name of Nocardiopsis iraniensis with considering the significant morphological, physiological, molecular and chemotaxonomical differences between Q70 and other species of Nocardiopsis.
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