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Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats

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Author(s): Kustiariyah Tarman | Ulrike Lindequist | Kristian Wende | Andrea Porzel | Norbert Arnold | Ludger A. Wessjohann

Journal: Marine Drugs
ISSN 1660-3397

Volume: 9;
Issue: 3;
Start page: 294;
Date: 2011;
Original page

Keywords: Indonesian marine fungi | algicolous fungi | antifungal | bioactive compounds

ABSTRACT
In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC50 value of 1.5 µg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 µg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.

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