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Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats

Author(s): Kustiariyah Tarman | Ulrike Lindequist | Kristian Wende | Andrea Porzel | Norbert Arnold | Ludger A. Wessjohann

Journal: Marine Drugs
ISSN 1660-3397

Volume: 9;
Issue: 3;
Start page: 294;
Date: 2011;
Original page

Keywords: Indonesian marine fungi | algicolous fungi | antifungal | bioactive compounds

In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC50 value of 1.5 µg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 µg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.

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