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Isolation and screening of soil Actinomycetes as source of antibiotics active against bacteria

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Author(s): Narendra Kumar, Ravi Kant Singh, Mishra SK, Singh AK, Pachouri UC

Journal: International Journal of Microbiology Research
ISSN 0975-5276

Volume: 2;
Issue: 2;
Start page: 12;
Date: 2010;
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Keywords: Antimicrobial activity | antibiotics | drug resistance | soil sample | Staphylococcus aureus

ABSTRACT
A total of 117 actinomycetes strains were isolated from the wasteland alkaline and garden soilsamples of the Ghaziabad and screened for their anti-bacterial activity. They were evaluated for theirinhibitory activities on four test microorganisms. Fifteen actinomycetes isolate which exhibited antimicrobialactivity against at least two of the test organisms and were characterized by conventional methods. Thecultural characteristics of isolates were also studies in different culture media. The results indicated that sixisolates were highly active against Staphylococcus aureus strains. Seven isolates were highly active with aninhibition zone more than 20 mm in diameter. Most of the isolates inhibited growth of the Gram negativebacteria tested. All the antibiotic producing actinomycetes were isolated at different temperatures from nonagricultural wasteland alkaline soil and compost rich garden soil. Fifteen isolates showed activity againstbacteria in which most of them from wasteland alkaline soil where the less interference by human foragriculture or other purpose. These microorganisms may have capability to produce some of the mostimportant medicines ever developed
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