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Isolation of Steroids from Acetone Extract of Ficus iteophylla

Author(s): I.A. Abdulmalik | M.I. Sule | A.M. Musa | A.H. Yaro | M.I. Abdullahi | M.F. Abdulkadir | H. Yusuf

Journal: British Journal of Pharmacology and Toxicology
ISSN 2044-2459

Volume: 2;
Issue: 5;
Start page: 270;
Date: 2011;
Original page

Keywords: Ficus iteophylla | 1: H- NMR | 13: C- NMR | DEPT | 3β-cholest-5-ene-3 | 23diol | 24 ethyl cholest-5-ene-3β-ol

Two steroids were isolated from the leaves of Ficus iteophylla (Family: moraceae) a plant popularly used in African traditional medicine to treat variety of illnesses. The leaf part of the plant was investigated phytochemically using a standard procedure. Schematic fractionation of its ethanol extract by acetone and methanol and subsequent column chromatography of the acetone fraction over silica gel G (60-120) mesh size led to the isolation of 3β-cholest-5-ene-3, 23diol (1) and 24 ethyl cholest-5-ene- 3β-ol (2). The structure of these two compounds was elucidated using 1H-NMR, 13C- NMR and DEPT analysis. To the best of our search this is the first report on the isolation of these compounds from the leaves of Ficus iteophylla.
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