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ISOTHIOCYANATES: NATURALLY OCCURRING HepG2 HUMAN LIVER CARCINOMA INHIBITOR

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Author(s): Prachi Bansal | Sharad Medhe | N Ganesh | MM Srivastava

Journal: International Journal of Bioassays
ISSN 2278-778X

Volume: 2;
Issue: 01;
Start page: 325;
Date: 2013;
Original page

Keywords: Carcinoma | Eruca sativa | Isothiocyanates

ABSTRACT
In vitro anticancer screening of different isothiocyanates (ITCs) [Allyl isothiocyanate (AITC), Phenylethyl isothiocyanate (PEITC) and Sulphoraphane (SUL)], derived from naturally occurring Eruca sativa seed oil (SO) against HepG2 human liver carcinoma cell line has been carried out using MTT, TBE and SRB bioassays. Combination of ITCs, in ratio (1:1:1) exhibited maximum percentage inhibition of 97.12%, 96.34% and 96.56% by MTT, TBE and SRB respectively against reference drug doxorubicin at concentration 50 ┬ÁM. Percent inhibition has been found to be more pronounced in isothiocyanates combination compared to its natural source E. sativa seed oil.
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