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iSPOT: A Web Tool for the Analysis and Recognition of Protein Domain Specificity

Author(s): Barbara Brannetti | Andreas Zanzoni | Luisa Montecchi-Palazzi | Gianni Cesareni | Manuela Helmer-Citterich

Journal: Comparative and functional genomics.
ISSN 1531-6912

Volume: 2;
Issue: 5;
Start page: 314;
Date: 2006;
Original page

Methods that aim at predicting interaction partners are very likely to play an important role in the interpretation of genomic information. iSPOT (iSpecificity Prediction Of Target) is a web tool (accessible at developed for the prediction of protein-protein interaction mediated by families of peptide recognition modules. iSPOT accesses a database of position specific residue-residue interaction frequencies for members of the SH3 and PDZ protein domain families. The software utilises this database to provide a score for any potential domain peptide interaction.
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