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Jak2 Tyrosine Kinase: A Potential Therapeutic Target for AT1 Receptor Mediated Cardiovascular Disease

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Author(s): Annet Kirabo | Peter P. Sayeski

Journal: Pharmaceuticals
ISSN 1424-8247

Volume: 3;
Issue: 11;
Start page: 3478;
Date: 2010;
Original page

Keywords: angiotensin II | Jak2 | AT1-receptor | hypertension

ABSTRACT
Patients with hypertension often manifest a dysregulated renin-angiotensin-aldosterone system (RAAS). Most of the available treatment approaches for hypertension are targeted towards the RAAS including direct renin inhibition, ACE inhibition, angiotensin II type 1 receptor (AT1-R) blockade, and aldosterone receptor antagonism. The Jak2 signaling pathway is intricately coupled to the AT1-R signaling processes involved in hypertension. Here, we review the involvement of Jak2 in the pathogenesis of hypertension, and its potential as a therapeutic target for treatment of AT1-R mediated cardiovascular disease. Jak2 may provide a rational therapeutic approach for patients whose blood pressure is not controlled by standard therapies.

Tango Jona
Tangokurs Rapperswil-Jona

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