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Kaurenic acid: An in vivo experimental study of its anti-inflammatory and antipyretic effects

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Author(s): Sosa-Sequera Miriam | Suarez Omar | Dalo Nelson

Journal: Indian Journal of Pharmacology
ISSN 0253-7613

Volume: 42;
Issue: 5;
Start page: 293;
Date: 2010;
Original page

Keywords: Antipyretic | anti-inflammatory | kaurenic acid | tetracyclic diterpenoid

ABSTRACT
Objective : This study was designed to investigate the anti-inflammatory and antipyretic effects of kaurenic acid (KA), a tetracyclic diterpenoid carboxylic acid, using in vivo experimental animal models. Material and Methods : The anti-inflammatory activity of KA was evaluated in rats, using egg albumin-induced paw edema (acute test) and Freund′s complete adjuvant-induced paw edema (subacute test), whereas the antipyretic effect was studied in rabbits by peptone-induced pyresis. Acute and subacute toxicity of KA were analyzed in NMRI mice. Results : KA showed anti-inflammatory and antipyretic properties, and the effect caused was significantly dose-related (P < 0.001) in both cases. The mean lethal doses of KA were 439.2 and 344.6 mg/kg for acute and subacute toxicity, respectively. Conclusion : On the basis of these findings, it may be inferred that KA has an anti-inflammatory and antipyretic potential.
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