Academic Journals Database
Disseminating quality controlled scientific knowledge

KEY PLAYERS IN INNATE IMMUNE RECOGNITION OF VIRUS INFECTION IN MAMMALS AND FISH

ADD TO MY LIST
 
Author(s): I Jakovlić | Y. B. Zhang | Q.J. Wu | Jian-Fang Gui

Journal: Ribarstvo : Croatian Journal of Fisheries
ISSN 1330-061X

Volume: 64;
Issue: 2;
Start page: 65;
Date: 2006;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: interferons; viral infection; dsrna; pkr; rig–i; tlr3; mda–5

ABSTRACT
Viral infection of mammalian cells activates an innate antiviral immune response characterized by production of interferon and subsequent enhanced transcription of interferon–stimulated genes important for antiviral defense. Cells recognize viral infection through various pathogen–associated molecular patterns, of which dsRNA seems to be the most important. In mammals, several gene products are important in recognition of dsRNA: RIG–I, TLR3, PKR and mda–5. Recent research proved that fish possess most of the key elements in recognition of viral infection which indicates that these mechanisms are very similar and evolutionary conserved in vertebrates.

Tango Rapperswil
Tango Rapperswil

     Save time & money - Smart Internet Solutions