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L-Serine Decreases Taurine Concentration in the Extracellular Fluid of Brain Slices

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Author(s): Kazutaka Shigemi | Koji Tanaka | Kohsuke Hayamizu | Donald Michael Denbow | Mitsuhiro Furuse

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 02;
Issue: 03;
Start page: 268;
Date: 2011;
Original page

Keywords: L-Serine | Chick | Brain Slice | Taurine | L-Alanine

ABSTRACT
L-Serine is considered a functional amino acid in the central nervous system, and induces sedation and hypnotic effects in some animal models of acute and chronic stress. Accordingly, while L-serine is a candidate anti-stress factor, the central mechanism of L-serine is not clear. The present study clarifies the action of L-serine using acute chick brain slices. We investigated the changes in some extracellular fluid amino acid concentrations in response to L-serine perfusion. Taurine concentration decreased while L-alanine concentration increased following L-serine perfusion. To examine the involvement of the taurine transporter, the effect of L-serine on the taurine concentration in the presence and absence of Na+ was also investigated. Na+ had no effect on taurine concentration induced by L-serine perfusion. These results suggest that L-serine has an ability to promote L-alanine synthesis facilitating the catabolism of taurine. In conclusion, L-serine modifies the metabolism of taurine and L-alanine in the extracellular space in chick brain.

Tango Jona
Tangokurs Rapperswil-Jona

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