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LAMIVUDINE-ARTESUNATE CO ADMINISTRATION ALTERS PIROXICAM MEDIATED ANALGESIA IN MICE

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Author(s): T.O Olurishe | H.O. Kwanashie | Anuka J.A. | H.M. Muktar

Journal: International Journal of Biomedical Research
ISSN 0976-9633

Volume: 2;
Issue: 3;
Start page: 222;
Date: 2011;
Original page

Keywords: analgesic | artesunate | drug interaction | lamivudine | pain

ABSTRACT
Lamivudine-Artesunate co-administration is common in HIV-malaria settings, as well as in prophylaxis from occupational HIV exposure and presumptive malaria treatment. Pain is a symptom often associated with malaria and HIV which is usually treated with piroxicam due to availability, affordability, and low addiction potential. This study evaluated possible analgesic effects of lamivudine and artesunate, and also the effect of lamivudine-artesunate co-administration on piroxicam mediated analgesia in mice using acetic acid induced writhing method. Animals received 21 day intraperitoneal treatments with vehicle, lamivudine, artesunate or lamivudine/artesunate co administration. The result showed that artesunate possessed analgesic properties, and also showed that piroxicam mediated analgesia was significantly reduced (p
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