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Lantana montevidensis Briq improves the aminoglycoside activity against multiresistant Escherichia coli and Staphylococcus aureus

Author(s): Sousa Erlanio | Almeida Thiago | Rodrigues Fabíola | Campos Adriana | Lima Sidney | Costa José

Journal: Indian Journal of Pharmacology
ISSN 0253-7613

Volume: 43;
Issue: 2;
Start page: 180;
Date: 2011;
Original page

Keywords: Aminoglycosides | antibacterial and modulatory activities | Lantana montevidensis Briq

Objective : In this work, we report the antibacterial and modulatory activity of Lantana montevidensis Briq. Materials and Methods : The antibacterial activities of leaf (LELm) and root (RELm) extracts alone or in association with aminoglycosides were determined by a microdilution test. Multiresistant strains of Escherichia coli (Ec 27) and Staphylococcus aureus (Sa 358) were used. Results : The results show the inhibitory activity of LELm against E. coli (minimal inhibitory concentration [MIC] 16 μg/mL) and S. aureus (MIC 128 μg/mL). The synergistic effect of the extracts and aminoglycosides was verified too. The maximum effects were obtained with RELm with gentamicin against E. coli with MIC reduction (312 to 2 μL). Conclusion : The data from this study are indicative of the activity antibacterial of extracts of L. montevidensis and its potential in modifying the resistance of aminoglycosides.
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