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LASSBio-596: Of the discovery to the pre-clinical studies [LASSBio-596: da descoberta aos ensaios pré-clínicos]

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Author(s): Patricia R. M. Rocco | Debora G. Xisto | Johnatas D. Silva | Magareth de F. F. M. Diniz | Reinaldo N. Almeida | Melissa N. Luciano | Isac A. Medeiros | Bruno C.Cavalcanti | José R. de O. Ferreira | Manoel O.de Moraes | Letícia V. Costa-Lotufo | Claudia do Ó Pessoa | Teresa Dalla-Costa | Vitória B. Cattani | Eliezer J. Barreiro | Lidia M. Lima

Journal: Revista Virtual de Química
ISSN 1984-6835

Volume: 2;
Issue: 1;
Start page: 10;
Date: 2010;
Original page

Keywords: Asthma | LASSbio-596 | Toxicity | Pharmacokinetic | Genotoxicity | Mutagenicity

ABSTRACT
This paper revised the trajectory of the discovery of a new antiasthmatic drug candidate, 2-[4-(1,4-thiazinan-4-ylsulfonyl)phenylcarbamoyl]benzoic acid (LASSBio-596) until the accomplishment of the first pre-clinical studies, with focus on LASSBio-596´s effects in murine asthma models, pharmokocinetic and toxicological studies and determination of genotoxicity and mutagenic profiles.

Tango Jona
Tangokurs Rapperswil-Jona

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