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LEAD TOXICITY AND POSTNATAL DEVELOPMENT OF OVARY

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Author(s): Ragini Sharma, Khushbu Panwar*, Isha Barber and Amit Purohit

Journal: International Journal of Pharmaceutical Sciences and Research
ISSN 0975-8232

Volume: 4;
Issue: 4;
Start page: 1575;
Date: 2013;
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Keywords: Lead acetate | Development | Ovary | Mice

ABSTRACT
Purpose: The course of human development from conception to adulthood is extremely complex. The developing organism is particularly vulnerable to toxic insult because of rapid cell division and differentiation and severely affected during gestation and lactation. The aim of the present study was to evaluate lead toxicity on the female reproductive system during neonatal period.Methods: Histopathological alterations in the developing ovaries were examined in neonates from birth to 21st day of weaning on specific days viz. 1, 7, 14 and 21st day of postnatal development. Lead acetate was administered via oral gavaging at 266 mg/kg/bodyweight and 1066 mg/kg/bodyweight to pregnant Swiss mice from 10th day of gestation to 21st day of lactation. Results: Studies conducted on females revealed mostly miscarriages, premature delivery and infant mortality. Lead suppresses the development of various follicles during fetal and neonatal life. Conclusion: It appears that lead interferes during specific events of ovarian developmental stages, which may create higher sensitivity for dysfunction in reproductive system during adulthood. The present investigation evaluates the relative influences of prenatal and postnatal exposure of lead acetate on growth and ovarian histology in female offspring during postnatal development.
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