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Learning About Gene Regulatory Networks From Gene Deletion Experiments

Author(s): Thomas Schlitt | Alvis Brazma

Journal: Comparative and functional genomics.
ISSN 1531-6912

Volume: 3;
Issue: 6;
Start page: 499;
Date: 2006;
Original page

Gene regulatory networks are a major focus of interest in molecular biology. A crucial question is how complex regulatory systems are encoded and controlled by the genome. Three recent publications have raised the question of what can be learned about gene regulatory networks from microarray experiments on gene deletion mutants. Using this indirect approach, topological features such as connectivity and modularity have been studied.
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