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Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence

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Author(s): Kcharchenko S.V. | Shapovalova Ye.Yu.

Journal: Морфологія
ISSN 1997-9665

Volume: 3;
Issue: 3;
Start page: 131;
Date: 2009;
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Keywords: rat’s embryogenesis | lung | kidney | paracetamol | nimesulide | lectins

ABSTRACT
467 rat embryos in the age from 13 to 22 day of the intrauterine life without visible damaging factors and under the influence of a therapeutic, subtoxic, toxic dose of paracetamol and nimesulide were investigated. Glycopolymers have been identified by three lectins, conjugated with peroxidase of horse-radish. It is established, that in cells and extracellular matrix of developing rat lungs and definitive kidney of control group contain peanut, soya and ricina glycopolymers. In process of control group rat lungs and definitive kidney embryogenesis there is constant lectin-receptor system redistribution. Paracetamol and nimesulide ingestion to pregnant rats leads to the redistribution of glycopolymers quantity and histotopogra-phy – receptors of soya, peanut and ricina lectins, changed in comparison with norm. Therapeutic and toxic dose of paraceta-mol and a toxic dose of nimesulide most strongly change histotopography and the quantity of lectins soya, peanut and ricina receptors in lungs. In definitive kidneys the therapeutic dose of paracetamol and a toxic dose of nimesulide has similar influ-ence.
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