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Levels of IGF-1 and Their Relationship with Bone Mineral Density in the Premenopausal Women with Fibromyalgia Syndrome

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Author(s): Onur Armağan | Esra Sırmagül | Ayşe Ekim | Başar Sırmagül | Funda Taşçıoğlu | Cengiz Öner

Journal: Turkish Journal of Rheumatology
ISSN 1300-5286

Volume: 23;
Issue: 04;
Start page: 118;
Date: 2008;
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Keywords: Fibromyalgia | IGF-1 | osteoporosis

ABSTRACT
Objective: The present study aims to compare bone mineral density (BMD) of healthy female patients with that of females with fibromyalgia syndrome (FMS), as well as to determine the relationship between insulin-like growth factor-1 (IGF-1) and BMD. Materials and Methods: Twenty-seven premenopausal women with FMS and 21 age-matched female controls were included in the study. Body mass index (BMI), IGF-1 and osteocalcin levels were assessed for all the cases. BMD measurements of the femoral neck and lumbar spine were done by using dual-energy X-ray absorptiometry.Results: Lomber and femoral bone mineral density were significantly lower in FMS patients compared with controls (p
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