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Licofelone- novel analgesic and anti-inflammatory agent for osteoarthritis: An overview

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Author(s): Gaur K | Kori M | Tyagi L | Singh V | Nema R | Tripathi P | Sharma C

Journal: Journal of Young Pharmacists
ISSN 0975-1483

Volume: 1;
Issue: 1;
Start page: 67;
Date: 2009;
Original page

Keywords: Licofelone | analgesic | anti-inflammatory

ABSTRACT
Licofelone (2-[6-(4-chlorophenyl)-2, 2-dimethyl-7-phenyl-2, 3-dihydro-1H-pyrrolizin-5-yl] acetic acid) is the first member of a new class of analgesic and anti-inflammatory drugs acting by dual mechanism inhibiting both cyclooxygenase (COX) and 5-lipooxygenase (5-LOX). Inhibition of 5-LOX may reduce the gastrointestinal toxicity associated with other non steroidal anti-inflammatory drugs (NSAIDs), which only inhibit cyclooxygenase (COX). It has been evaluated for the treatment of osteoarthritis (OA), the most common form of arthritis. It has been found to be significantly effective in Phase III clinical trials conducted on patients of osteoarthritis. The present review describes the pharmacological and clinical developments of licofelone as a dual inhibitor for COX and 5-LOX.
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