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Life Claiming Anaphylaxis to Intravenous Ceftriaxone after Negative Skin Test

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Author(s): Dr. Prashant K | Dr. Girdhar K | Dr. Raktima A | Dr. Gaurav K

Journal: Indian Anaesthetists' Forum
ISSN 0973-0311

Volume: 6;
Issue: 2;
Start page: 1234;
Date: 2005;
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Keywords: Ceftriaxone | Hypersensetivity | Skin Test

ABSTRACT
Antibiotic prophylaxis before surgical procedures is commonly practiced. Hypersensitivity reactions to antibacterial drugs are most feared complications; which have varying grades of presentation. Skin testing are commonly applied to detect allergy but that can have false negatives. We report a case of severe anaphylaxis leading ultimately to fatal outcome after negative skin testing. Prior history of allergy of any kind and exposure to ceftriaxone was excluded. Even the best antishock management could not help. This observation clearly demonstrates the limit of screening tests for the diagnosis of sensitization against drugs.
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