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Lipase Catalysed Kinetic Resolution of Stiripentol

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Author(s): Elisabeth Egholm Jacobsen | Thorleif Anthonsen | Mohammed Farrag El-Behairy | Eirik Sundby | Mohamed Nabil Aboul-Enein | Mohamed Ibrahim Attia | Aida Abd El-Sattar El-Azzouny | Kamilia M. Amin | Mohamed Abdel-Rehim

Journal: International Journal of Chemistry
ISSN 1916-9698

Volume: 4;
Issue: 1;
Date: 2012;
Original page

ABSTRACT
Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24. This allowed isolation of (3S)-Stiripentol with an ee of 86 % and the corresponding (3R)-butanoate with an ee of 87 %. Enzymatic hydrolysis of the ester product gave (3R)-Stiripentol with 94 % ee.
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