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Lipofundin 20% induces hyperlipidemia and oxidative stress in male Sprague Dawley rats

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Author(s): L DelgadoRoche | Á FragaPerez | M A BequerViart | Y Hernandez-Matos

Journal: Veterinary World
ISSN 0972-8988

Volume: 5;
Issue: 3.000;
Start page: 133;
Date: 2012;
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Keywords: Lipofundin 20% | hyperlipidemia | oxidative stress | parenteral nutrition

ABSTRACT
Lipofundin is a lipid emulsion used in parenteral nutrition. One of adverse effects reported for this kind of pharmaceutical products is the capacity to induce oxidative stress, which is an important contributor of many diseases, such as cardiovascular diseases. The aim of the present work was to evaluate the effects of Lipofundin administration on lipid profile and serum redox biomarkers, in order to determine if both events are responsible for the undesirable effects of this lipid emulsion. Male Sprague Dawley rats were intravenously administered with 2 mL/kg of Lipofundin 20% daily, for 8 days. Then, serum lipid profile and redox biomarkers were spectrophotometrically determined. A significant increase (p
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