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Liquisolid compacts of glimepiride: an approach to enhance the dissolution of poorly water soluble drugs

Author(s): Sachin Kumar Singh 1, 4*, Dev Prakash1, K.K. Srinivasan2, K Gowthamarajan3

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 7;
Start page: 2263;
Date: 2011;
Original page

Keywords: Glimepiride | non-volatile liquid | liquisolid tablets | Stability Studies | DSC | PXRD

The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was designed to evaluate the effects of different formulation variables, i.e. type of non-volatile liquid vehicles and drug concentrations, on drug dissolution rates. The liquisolid tablets were formulated with Propylene glycol, as liquid vehicle. Microcrystalline cellulose was used as a carrier material, silica as a coating material and Croscaremellose as a disintegrant. In vitro drug dissolution profiles of the liquisolid formulations were studied and compared with direct compressed non- micronizedand micronized tablets of Glimepiride using USP II, paddle apparatus at 50 rpm for 60 minutes using 900ml of 0.05 M Phosphate Buffer, pH 7.5. Stability studies were carried out to evaluate the stability of the tablets under humid conditions (250C/ 75% relative humidity). It was found that liquisolid tablets formulated with propylene glycol produced high dissolution profile with acceptable tablet properties. The stability studies showed that the dissolution profiles of liquisolid tablets prepared with propylene glycol were not affected by ageing significantly. Differential Scanning Calorimetry revealed that drug particles in liquisolid formulations were completely solubilised. This was further supported by the powder X-ray diffraction studies of pure drug and the liquisolid powder system, which showed the decrease in crystallinity of the drug in liquisolid system. This decrease in crystallinity of drug was also one of the factors in enhancement of dissolution of Glimepiride.

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