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Living unrelated donor kidney transplantation: A fourteen-year experience

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Author(s): Ignjatović Ljiljana | Jovanović Dragan | Kronja Goran | Dujić Aleksandar | Marić Mihailo | Ignjatović Dragan | Hrvačević Rajko | Kovačević Zoran | Petrović Milija | Elaković Dejan | Marenović Tomislav | Lukić Zoran | Trkuljić Miroljub | Stanković Bratislav | Maksić Đoko | Butorajac Josip | Čolić Miodrag | Drašković-Pavlović Biljana | Kapulica-Kuljić Nada | Drašković Nada | Mišović Sidor | Stijelja Borislav | Milović Novak | Toševski Perica | Filipović Nikola | Romić Predrag | Jevtić Miodrag | Drašković Miroljub | Vavić Neven | Paunić Zoran | Radojević Milorad | Bjelanović Zoran | Tomić Aleksandar | Aleksić Predrag | Košević Branko | Mocović Dejan | Bančević Vladimir | Magić Zvonko | Vojvodić Danilo | Balint Bela | Ostojić Gordana | Tukić Ljiljana | Murgić Jadranka | Pervulov Svetozar | Rusović Siniša | Sjeničić Goran | Bućan Vesna | Milavić-Vujković Merica | Jandrić Dušan | Raičević Ranko | Mijušković Mirjana | Obrenčević Katarina | Pilčević Dejan | Čukić Zoran | Petrović Marijana | Petrović Milica | Tadić Jelena | Terzić Brankica | Karan Željko | Bokonjić Dubravko | Dobrić Silva | Antunović Mirjana | Bokun Radmila | Dimitrijević Jovan | Vukomanović-Đurđević Biserka

Journal: Vojnosanitetski Pregled
ISSN 0042-8450

Volume: 67;
Issue: 12;
Start page: 998;
Date: 2010;
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Keywords: kidney transplantation | tissue donors | treatment outcome | transplantants | graft survival | graft rejection | risk assessment

ABSTRACT
Background. In countries without a national organization for retrieval and distribution of organs of the deceased donors, problem of organ shortage is still not resolved. In order to increase the number of kidney transplantations we started with the program of living unrelated - spousal donors. The aim of this study was to compare treatment outcome and renal graft function in patients receiving the graft from spousal and those receiving ghe graft from living related donors. Method. We retrospectively identified 14 patients who received renal allograft from spousal donors between 1996 and 2009 (group I). The control group consisted of 14 patients who got graft from related donor retrieved from the database and matched than with respect to sex, age, kidney disease, immunological and viral pretransplant status, the initial method of the end stage renal disease treatment and ABO compatibility. In the follow-up period of 41 ± 38 months we recorded immunosuppressive therapy, surgical complications, episodes of acute rejection, CMV infection and graft function, assessed by serum creatinine levels at the beginning and in the end of the follow-up period. All patients had pretransplant negative cross-match. In ABO incompatible patients pretransplant isoagglutinine titer was zero. Results. The patients with a spousal donor had worse HLA matching. There were no significant differences between the groups in surgical, infective, immunological complications and graft function. Two patients from the group I returned to hemodialysis after 82 and 22 months due to serious comorbidities. Conclusion. In spite of the worse HLA matching, graft survival and function of renal grafts from spousal donors were as good as those retrieved from related donors.
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