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Low-count bacteriuria in refractory idiopathic detrusor overactivity versus controls

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Author(s): Colin Walsh | Wendy Allen | Katrina Parkin | Chinmoy Mukerjee | Kate Moore

Journal: Urogynaecologia International Journal
ISSN 1121-3086

Volume: 25;
Issue: 1;
Start page: e4;
Date: 2011;
Original page

Keywords: Bacteriuria | Detrusor overactivity | Overactive bladder | Refractory | Urinary tract infection

ABSTRACT
Background. Previous studies suggest an association between idiopathic detrusor overactivity (IDO) and high-count bacteriuria (>105 CFU/mL). Recently, the importance of low-count bacteriuria (103–105 CFU/mL) in dysuric women with has been recognised. However, the optimal microbiological threshold for women with overactive bladder (OAB) symptoms remains unclear. Design and Methods A 2-year prospective cohort study, to examine the incidence of low-count and high-count bacteriuria in women with refractory IDO (RIDO) versus a control group without OAB symptoms. Women with dysuria, voiding dysfunction or recent urethral instrumentation were excluded. Mid-stream urine (MSU) specimens were collected during acute symptomatic exacerbation in the IDO group and cultured at the 103 CFU/mL threshold. Statistical analysis was performed using Statsdirect statistical package 2.7.2. Results. Between November 2007 and November 2009, 218 study MSU specimens were collected. Both the overall incidence of any significant bacteriuria ≥103 CFU/mL (P
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