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Low-dose steroid pretreatment ameliorates the transient impairment of liver regeneration

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Author(s): Toshihito Shibata | Toru Mizuguchi | Yukio Nakamura | Masaki Kawamoto | Makoto Meguro | Shigenori Ota | Koichi Hirata | Hidekazu Ooe | Toshihiro Mitaka

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 18;
Issue: 9;
Start page: 905;
Date: 2012;
Original page

Keywords: Liver regeneration | Radiofrequency ablation | Steroid | Tumor necrosis factor | Hepatectomy

ABSTRACT
AIM: To determine if liver regeneration (LR) could be disturbed following radiofrequency (RF) ablation and whether modification of LR by steroid administration occurs. METHODS: Sham operation, partial hepatectomy (PH), and partial hepatectomy with radiofrequency ablation (PHA) were performed on adult Fisher 344 rats. We investigated the recovery of liver volume, DNA synthetic activities, serum cytokine/chemokine levels and signal transducers and activators of transcription 3 DNA-binding activities in the nucleus after the operations. Additionally, the effects of steroid (dexamethasone) pretreatment in the PH group (S-PH) and the PHA group (S-PHA) were compared. RESULTS: The LR after PHA was impaired, with high serum cytokine/chemokine induction compared to PH, although the ratio of the residual liver weight to body weight was not significantly different. Steroid pretreatment disturbed LR in the S-PH group. On the other hand, low-dose steroid pretreatment improved LR and suppressed tumor necrosis factor (TNF)-α elevation in the S-PHA group, with recovery of STAT3 DNA-binding activity. On the other hand, low-dose steroid pretreatment improved LR and suppressed TNF-α elevation in the S-PHA group, with recovery of STAT3 DNA-binding activity. CONCLUSION: LR is disturbed after RF ablation, with high serum cytokine/chemokine induction. Low-dose steroid administration can improve LR after RF ablation with TNF-α suppression.
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