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Low molecular fucoidan and its macromolecular complex with bee venom melittin

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Author(s): G. T. Mavlonov | J. M Lee | Lee Shin | T. H. Yi | I. Y. Abdurakhmonov

Journal: Advances in Bioscience and Biotechnology
ISSN 2156-8456

Volume: 02;
Issue: 04;
Start page: 298;
Date: 2011;
Original page

Keywords: Fucoidan | Free Radical Depolymerization | Melittin | Anti-Inflammatory Activity

ABSTRACT
Low molecular weight (LMW) fucoidan, obtained by free radical depolymerization of high molecular polysaccharide extract of brown algae Hizikia fusiformis, was complexed with HPLC purified bee venom melittin. Water soluble form of the LMW fucoidan – melittin complex shows increased anti-inflammatory activity, inhibiting the production of nitric oxide in murine macrophage cell line Raw 264.7. The LMW fucoidan:melitin complex obtained in this study showed good biological activities, resulting in 2-fold reduction of the melittin toxicity. The fucoidan: melittin macromolecular complex obtained should be useful in future therapeutic applications.
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