Academic Journals Database
Disseminating quality controlled scientific knowledge

Lupus eritematoso sistémico en niños: caracterización de 30 casos

Author(s): Maria de los Reyes Chacón de Petrola | Velmar Quintero | Maria Elisa Flores Chavez | Alcira Torres

Journal: Salus Online
ISSN 1316-7138

Volume: 13;
Issue: 2;
Start page: 11;
Date: 2009;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: pediatic systemic lupus erythematosus | diagnosis SLE | pediatric SLE

Pediatric systemic lupus erythematosus: characterization of 30 cases Systemic Lupus Erythematosus (SLE) in children is usually severe, with major organic involvement. In the present study the disease was characterized; diagnostic criteria were established, and initial symptoms were related to age and evolution of the patient. After informed written consent, a prospective longitudinal study was carried out on 30 patients between 6 and 18 years of age (Immunology Unit - Enrique Tejera Hospital City - January 2006-July 2007) (22 with follow-ups every three months, January 2006 - July 2007, and 8 with prior follow-ups: review of medical records), with a minimum of 4 criteria (American College of Rheumatology) for SLE. 82.8% female. Average age of onset: 12.37 (± 3.35); male 14.4 ± 4.7,female 15.3 ± 4.1 (P> 0.05). Most frequent initial diagnostic criteria: immunological, 68.9%, (DNA antibodies: 60% - Anti Sm: 28.57% - antibodies: 27.77%), positive antinuclear antibodies 68.9% renal impairment 62.1%. Most frequent association: with arthritis, antinuclear antibodies and immune disorders. Developments during follow-ups: most frequent sign, arthritis and/or arthralgia in one or more joints,72.4%; incidence decreased among older children. Skin disorders were more common in children under 10 years of age, and temperature rise in those aged 11 to 15. Renal impairment was present in 50% of children aged between 11 and 15. Poor outcome was associated with: 1) discoid rash, arthritis, kidney or neurological disorders, serositis, and/or fever. 2) 5 or more positive criteria. 3) Decreased creatinine clearance. 4) Decreased serum complement
Affiliate Program     

Tango Rapperswil
Tango Rapperswil