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Macroscopic extent of gastric mucosal atrophy: increased risk factor for esophageal squamous cell carcinoma in Japan

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Author(s): Akiyama Tomoyuki | Inamori Masahiko | Iida Hiroshi | Endo Hiroki | Hosono Kunihiro | Yoneda Kyoko | Fujita Koji | Yoneda Masato | Takahashi Hirokazu | Goto Ayumu | Abe Yasunobu | Kirikoshi Hiroyuki | Kobayashi Noritoshi | Kubota Kensuke | Saito Satoru | Rino Yasushi | Nakajima Atsushi

Journal: BMC Gastroenterology
ISSN 1471-230X

Volume: 9;
Issue: 1;
Start page: 34;
Date: 2009;
Original page

ABSTRACT
Abstract Background We aimed to estimate whether the macroscopic extent of gastric mucosal atrophy is associated with a risk for esophageal squamous cell carcinoma using a case-control study in Japanese subjects, a population known to have a high prevalence of CagA-positive H. pylori infection. Methods Two hundred and fifty-three patients who were diagnosed as having esophageal squamous cell carcinoma, and 253 sex- and age-matched controls were enrolled in the present study. The macroscopic extent of gastric mucosal atrophy was evaluated based on the Kimura and Takemoto Classification. A conditional logistic regression model with adjustment for potential confounding factors was used to assess the associations. Results Body gastritis, defined endoscopically, was independently associated with an increased risk for esophageal squamous cell carcinoma. Conclusion Our findings suggest that macroscopic body gastritis may be a risk factor for esophageal squamous cell carcinoma in Japan. Further studies are needed to confirm these findings.
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