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Magnetic chitosan for drug targeting and in vitro drug delivery response

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Author(s): Alexandru Mihai Grumezescu | Crina Saviuc | Alina Holban | Radu Hristu | Cristina Coritoru | George Stanciu | Carmen Chifiriuc | Dan Mihaiescu | Paul Balaure | Veronica Lazar

Journal: Biointerface Research in Applied Chemistry
ISSN 2069-5837

Volume: 1;
Issue: 5;
Start page: 160;
Date: 2011;
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Keywords: chitosan | cephalosporins | magnetite | biomaterial | drug targeting | drug delivery

ABSTRACT
The magnetic targeted drug delivery system is one of the most attractive strategies of delivering drugs to the area of interest. Magnetic drug targeting is based on using magnetic drug carrier particles to selectively deliver drugs to a specific site inside the body by using an external magnet field to attract and retain them there. Our study was focused to the synthesis, characterization and in vitro drug delivery response of magnetic hybrid material based Fe3O4/chitosan/cephalosporins (Cefepime, Ceftriaxone, Cefuroxime, Cefoperazone, Cefpirome, Cefaclor). Magnetic materials were characterized by CLSM (Confocal Laser Scanning Microscopy) and µATR-FT-IR (Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy). All these hybrid materials have been prepared in order to develop a magnetic drug delivery system and can be utilized to facilitate the targeted drug delivery of cephalosporins. The hybrid materials are obtained under mild conditions without any organic solvents and surfactants, which are more suitable for pharmaceutical applications.
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