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Magnetic Resonance Spectroscopic Imaging (MRSI) Study of Breast Cancer

Author(s): K. B. Ashok

Journal: International Journal of Collaborative Research on Internal Medicine & Public Health
ISSN 1840-4529

Volume: 3;
Issue: 3;
Start page: 278;
Date: 2011;
Original page

Keywords: Breast Cancer | MRSI | MRI | Cancer Biomarkers

Background: Breast cancer is the fifth most common cause of cancer death worldwide and most seriousform of neoplastic diseases in both developed and developing countries. Mammography and ultrasoundare the most often used screening methods in breast cancer. Magnetic Resonance Imaging (MRI) uses theprotons in water and fat to create the image of breast cancer. But recent studies says neoplastic breastlesions contains elevated choline concentration (tCho) and altered mean apparent diffusion coefficient(ADC) which can be used as good biomarkers to evaluate the cancer stages even follow up theNeoadjuvent Chemotherapy (NACT).Aim & Objectives:1. To evaluate the relation of age, tCho concentration and mean ADC with breast cancer.2. To estimate the correlation between the factors.3. To calculate the main difference between breast cancer patient before and after menopause.Methods/Study Design: This was a cross sectional, observational study done on 14 randomly selecteddiagnosed stage I breast cancer patients newly registered in surgery department of All India Institute ofMedical Sciences, New Delhi, India during 3 months study period. Intentionally 7 of them were selectedto be postmenopausal and rest 7 premenopausal. Patients with claustrophobia, serious illness, pacemakeror associated diseases were excluded. Volunteers were selected by lottery method after confirmation ofabsence of the exclusion criteria in them. All the breast MRS images were taken only after signing theconsent form of being a volunteer for the study with breast coil. All the spectroscopic images wereanalyzed with computer technologies and SPPS software with the help of non-parametric statistical tests.Results/Findings: Mean age of patients were 44.85±6.97 where in premenopausal and postmenopausalwomen it was 40.14±4.59 and 49.57±5.26 respectively. tCho concentration was high in postmenopausalwomen (4.85±2.64 mmol/kg vs 3.72±1.64) where unlike to them premenopausal women showed highermean ADC values (1.02±0.20 vs 0.91±0.09). All together weak correlation (r= 0.439) found in betweenthe tCho and mean ADC where age and tCho were weakly correlated among the premenopausal patients(r=0.440). Among the postmenopausal women strong correlation found in between age tCho and meanADC (r=0.620) and age and mean ADC (r=0.498).Study Limitations: It was short term study with very less population of same category of breast cancerwhich can be more appreciated if done in a large population cohort study design though as a pilot studythe aims were satisfactorily reached.Conclusion: Postmenopausal women show adverse conditions in breast cancer and using tCho and meanADC as biomarkers; the management process becomes easier for a doctor.

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