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Main procedures for evaluating the behavior in advanced postnatal toxicology studies

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Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández | Yulieé López Feria | Yamilka Soroa Millán

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 29;
Start page: 26;
Date: 2010;
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Keywords: Postnatal toxicology | behavior | exploratory activity | active and passive avoidance | orientation movement in inclined plane | hot plate test | rotating rod test

ABSTRACT
The behavior constitutes one of the appraisable parameters of more importance in the reproduction toxicology studies, linked mainly to the postnatal stage of the new breeding in one generation and multigenerational studies. In this article we had for objective to offer the procedures to carry out the evaluation of the open field exploratory activity, active and passive avoidance test in mice, evaluation of the orientation movement in inclined plane, evaluation of the response to the hot plate test and lastly the procedure for the evaluation of the response to the rotating rod test. The authors group hopes that this article is since of great utility for the toxicologists that visit the Journal, in this document we highlight the procedures eminently of animal behavior, very useful in the toxicology reproduction studies, where it is thoroughly explained the principle of each one of these tests and as carrying out it. It concerns the researchers to give a scientific explanation to the results that they obtain in each one from these tests when evaluating yours products.
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