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Malignant prolactinoma: A rare case report

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Author(s): Trivedi Priti | Gupta Anuja | Pasricha Sunil | Patel Dipak

Journal: Neurology India
ISSN 0028-3886

Volume: 58;
Issue: 5;
Start page: 778;
Date: 2010;
Original page

Keywords: MIB-1 | pituitary carcinoma | p53

ABSTRACT
Pituitary carcinomas are rare adenohypophyseal tumors with cerebrospinal or extracranial metastasis. None of the histologic findings distinguish pituitary adenoma from carcinoma. We describe clinico-pathological and immunohistological features of malignant prolactinoma. The patient initially presented with a prolactin-secreting pituitary adenoma. The tumor showed aggressive clinical course presenting with repeated recurrences and eventually metastasized to multiple bones. MIB-1 and p53 labeling indices were also compared in primary adenoma, recurrent invasive adenoma and metastatic tumor.
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