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Marchiafava-Bignami disease: Role of neuroimaging in the diagnosis and management of acute disease

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Author(s): Bano Shahina | Mehra Shibani | Yadav Sacchida | Chaudhary Vikas

Journal: Neurology India
ISSN 0028-3886

Volume: 57;
Issue: 5;
Start page: 649;
Date: 2009;
Original page

Keywords: Corpus callosum | choline/creatine ratio | Marchiafava-Bignami disease

ABSTRACT
Marchiafava-Bignami disease (MBD), a rare disorder most commonly seen in patients with a history of alcohol consumption, involves progressive demyelination and subsequent necrosis of the corpus callosum. Because clinical signs are nonspecific, the role of computed tomography and magnetic resonance imaging is essential to confirm the diagnosis. Early diagnosis with imaging and prompt treatment may improve the prognosis of MBD.

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