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Mecanismo de acción del anticuerpo monoclonal ES-78 contra la fasciolosis Action mechanism of ES-78 monoclonal antibody against fasciolosis

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Author(s): Ricardo Marcet Sánchez | Mabel Figueredo Pino | Jorge Sarracent Pérez

Journal: Revista Cubana de Medicina Tropical
ISSN 0375-0760

Volume: 56;
Issue: 3;
Start page: 203;
Date: 2004;
Original page

Keywords: Fasciola hepatica | protección pasiva | anticuerpo monoclonal ES-78 | citotoxicidad mediada por anticuerpos | Fasciola hepatica | passive protection | ES-78 monoclonal antibody | dependent cell citotoxicity

ABSTRACT
Se reportó recientemente que el anticuerpo monoclonal ES-78 es capaz de conferir protección pasiva contra fasciolosis. Se realizó la identificación de uno de los mecanismos mediante el cual ejerce su acción protectora contra la enfermedad. Este anticuerpo monoclonal fue capaz de realizar citotoxicidad mediada por anticuerpo tanto sobre células Raji marcadas con el antígeno de excreción-secreción de Fasciola hepatica como sobre parásitos recién desenquistados. Este anticuerpo monoclonal no inhibió la actividad de cisteíno proteinasa utilizando azocaseína como sustrato.It was recently reported that the ES-78 monoclonal antibody is capable of giving passive protection against fasciolosis. One of the mechanisms by which it exerts its protective action against the disease was identified. We also demonstrated in this report the capability of this monoclonal antibody to produce antibody dependent cell citotoxicity on Raji cells coated with excretory-secretory antigens, as well as on newly disencysted parasites.. No inhibition of proteinase activity was found in presence of this monoclonal antibody when azocasein substrate was used.
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