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Mechanisms involved in calcium oxalate endocytosis by Madin-Darby canine kidney cells

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Author(s): Campos A.H. | Schor N.

Journal: Brazilian Journal of Medical and Biological Research
ISSN 0100-879X

Volume: 33;
Issue: 1;
Start page: 111;
Date: 2000;
Original page

Keywords: calcium oxalate | DCK cells | mechanisms of endocytosis | renal stone

ABSTRACT
Calcium oxalate (CaOx) crystals adhere to and are internalized by tubular renal cells and it seems that this interaction is related (positively or negatively) to the appearance of urinary calculi. The present study analyzes a series of mechanisms possibly involved in CaOx uptake by Madin-Darby canine kidney (MDCK) cells. CaOx crystals were added to MDCK cell cultures and endocytosis was evaluated by polarized light microscopy. This process was inhibited by an increase in intracellular calcium by means of ionomycin (100 nM; N = 6; 43.9% inhibition; P

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