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MEGX: A DYNAMIC LIVER FUNCTION TEST

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Author(s): Remeth J Dias

Journal: Pharma Research
ISSN 0975-8216

Volume: 02;
Issue: 01;
Start page: 105;
Date: 2009;
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Keywords: Monoethylglycinexylidide | lidocaine metabolism | liver function tests | hepatic function.

ABSTRACT
The dynamic liver function tests are more sensitive and provide qualitative or quantitative assessments of thefunctional capacity of the liver. The dynamic tests like indocyanine green, caffeine clearance and galactoseelimination capacity are more time consuming, technically cumbersome and expensive while aminopyrineand erythromycin breath tests have the potential hazard of exposure to radioactive compounds. Whereas,Monoethylglycinexylidide (MEGX) test is a simple, rapid test and can complement established static liverfunction tests in assessing liver function.Lidocaine is metabolised primarily by the liver cytochrome P450 through oxidative N- dealkylation toMEGX. Because of the relatively high hepatic extraction of lidocaine, MEGX test depends on both hepaticmetabolic capacity and hepatic blood flow. The formation of MEGX in serum can be determined by variousmethods like fluorescence polarization immunoassay technique, high performance liquid chromatographyand gas liquid chromatography methods.Various studies have shown that life threatening complications can be developed in patients with MEGXvalues
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