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Meta-analysis of case-referent studies of specific environmental or occupational pollutants on lung cancer

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Author(s): Mahjub H | Sadri G

Journal: Indian Journal of Cancer
ISSN 0019-509X

Volume: 43;
Issue: 4;
Start page: 169;
Date: 2006;
Original page

Keywords: Environmental | lung cancer | meta-analysis | pollution

ABSTRACT
BACKGROUND: Meta-analysis is a statistical tool for combining and integrating the results of independent studies of a given scientific issue. The present investigation was initiated to investigate case-referent studies of lung cancer risk from specific environmental and occupational pollutants, using detailed individual exposure data. MATERIALS AND METHODS: To examine the risk of lung cancer associated with environmental and occupational pollutants, a meta-analysis of published case-control studies was undertaken using a random effects model. For this study, the papers were selected for review from electronic search of PubMed, Medline and Google Scholar during 1990-2006. The principal outcome measure was the odds ratio for the risk of lung cancer. Twelve study reports detailing the relationship between the lung cancer and the type of exposure were identified. RESULTS: The odds ratio of asbestos, cooking fuel, cooking fumes, motor and diesel exhaust related to lung cancer were 1.67, 1.99, 2.52 and 1.42 ( P < 0.001), respectively. The odds ratio of metal fumes related to lung cancer was 1.28 (0.001
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