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Metabolic dysfunction within the anterior limbic network in bipolar disorder: a model for studying new treatments

Author(s): Stephen M. Strakowski | Caleb M. Adler | Melissa P. DelBello

Journal: Neuropsychiatria i Neuropsychologia
ISSN 1896-6764

Volume: 1;
Issue: 1;
Start page: 5;
Date: 2006;
Original page

Keywords: bipolar disorder | functional magnetic resonance imaging (fMRI) | magnetic resonance spectroscopy (MRS) | anterior limbic network

Bipolar disorder is a dynamic psychiatric condition that,early in its course, progresses to a recurrent and lifelongillness. Although a number of treatment options nowexist, identifying effective medications for a specificbipolar individual requires trial-and-error in the absenceof useful treatment response predictors. However, newimaging research suggests that bipolar disorder mayresult from hypermetabolism within specific brainregions constituting the anterior limbic network. Thismodel of bipolar disorder may provide targets formonitoring treatment response and ultimately holds thepromise of developing predictors of treatment response.This article provides a focused review of evidencesupporting this neurophysiologic model of bipolardisorder and highlights how this model may lead tostudies of medication effects and treatment response.
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