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Metabolic syndrome components among children born small for gestational age: analysis of the first decade of life

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Author(s): Małgorzata Szałapska | Renata Stawerska | Maciej Borowiec | Wojciech Młynarski | Andrzej Lewiński | Maciej Hilczer

Journal: Pediatric Endocrinology, Diabetes and Metabolism
ISSN 2081-237X

Volume: 16;
Issue: 4;
Start page: 270;
Date: 2010;
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Keywords: metabolic syndrome | small for gestational age | insulin resistance | hypertension | children

ABSTRACT
Introduction and aim of the study: In children born small for gestational age (SGA), some of the metabolic syndrome (MS) components are observed. The goal of the study was an evaluation of the incidence of particular components of MS in 5-9-years-old SGA children. Material and methods: Ninety-one prepubertal SGA children (34 boys and 57 girls) were qualified into the study, aged 4.78-9.75 yrs (6.9?1.37 yrs). In each child, the actual height, weight and waist circumference, as well as blood pressure were measured. Fasting triglyceride and HDL-cholesterol levels were assessed. Glucose and insulin concentrations were estimated at fasting state and during the oral glucose tolerance test (OGTT). On the basis of the obtained results, BMI SDS, waist-to-height ratio and the insulin resistance indices (IRI), as defined by HOMA and Belfiore, were calculated. Results: Visceral obesity was diagnosed in 14 cases, out of which, 5 cases additionally presented with, at least, two other components of MS, while in 5 other cases, one component of MS was additionally confirmed, most frequently as arterial hypertension (HA). In all the analysed SGA children, normal glucose tolerance was observed. Insulin resistance was identified in 13 children, acc. to IRIBelfiore, but not in any child, acc. to IRIHOMA. HA was diagnosed in 30 (33%) prepubertal SGA children, emphasising the fact that its concomitance with visceral obesity was observed in a half of the cases only. Children with HA were taller and heavier, more frequently demonstrating insulin resistance. Conclusions: In 5-9-year-old SGA children, a high frequency of particular diagnostic criteria for the MS is observed

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